Against an imaginary background of the Hadean Earth, three reaction flasks represent ongoing and various attempts to recreate “Darwin's warm little pond” in a laboratory setting. Examples of recent progress and experimental systems being studied by chemists and biochemists in this collective quest to understand the origins of life are represented by the schemes drawn on the hood sash. (Cover design by Nicholas Hud, David Fialho, and Ram Krishnamurthy with fume hood background adapted from NASA/JPL-Caltech)