Enhanced nonenzymatic ligation of homopurine miniduplexes: support for greater base stacking in a pre-RNA world.

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TitleEnhanced nonenzymatic ligation of homopurine miniduplexes: support for greater base stacking in a pre-RNA world.
Publication TypeJournal Article
Year of Publication2013
AuthorsKuruvilla, E, Schuster, GB, Hud, NV
JournalChemBioChem
Volume14
Issue1
Pagination45-8
Date Published2013 Jan 2
ISSN1439-7633
KeywordsBase Pairing, DNA, Hydrogen Bonding, Purine Nucleotides, RNA
Abstract

The ancestors of RNA? There is a long-standing proposal that contemporary nucleic acids might have evolved from RNA-like polymers that utilized only purine-purine base pairs. Here we demonstrate the great advantage that increased nucleobase stacking area provides for nonenzymatic ligation.
DOI10.1002/cbic.201200601
Alternate JournalChembiochem
PubMed ID23225671