| Title | Enhanced nonenzymatic ligation of homopurine miniduplexes: support for greater base stacking in a pre-RNA world. |
| Publication Type | Journal Article |
| Year of Publication | 2013 |
| Authors | Kuruvilla, E, Schuster, GB, Hud, NV |
| Journal | ChemBioChem |
| Volume | 14 |
| Issue | 1 |
| Pagination | 45-8 |
| Date Published | 2013 Jan 2 |
| ISSN | 1439-7633 |
| Keywords | Base Pairing, DNA, Hydrogen Bonding, Purine Nucleotides, RNA |
| Abstract | The ancestors of RNA? There is a long-standing proposal that contemporary nucleic acids might have evolved from RNA-like polymers that utilized only purine-purine base pairs. Here we demonstrate the great advantage that increased nucleobase stacking area provides for nonenzymatic ligation. |
| DOI | 10.1002/cbic.201200601 |
| Alternate Journal | Chembiochem |
| PubMed ID | 23225671 |
Georgia Institute of Technology
North Avenue, Atlanta, GA 30332
Phone: 404-894-2000